Eh, not really. I got a budget gaming pc (AMD Phenom II 950 3.1ghz Quad, 4gb, ATI 4870) and it defaulted to Ultra High. The only bit of annoyance is it doesn't let you alt tab. One thing I did notice that dramatically affected fps vs Fallout 3 is that light sources are way, way more realistic (This results in some rare chugging, such as a casino that has a reflective car inside, with 8 light sources shining down on it) and 2d textures, such as grass, are anti-aliased. Overall though the game looks like what Fallout 3 should of looked like, faces don't look like clay anymore, kind of a plus in my book.